Ted J. Kaptchuk
Selected Articles
Clinical Research
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Quantifying and controlling the impact of regression to the mean on randomized controlled trials in epilepsy. Epilepsia (2023)
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Effectiveness of conditioned open-label placebo with methadone in treatment of opioid use disorder: A randomized clinical trial. JAMA Network Open
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Improving medication tolerance: A pilot study in disorders of gut-brain interaction treatment with tricyclic antidepressants. Journal of Clinical Gastroenterology (2022)
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Effect of open-label placebo on children and adolescents with functional abdominal pain or irritable bowel syndrome: A randomized clinical trial. JAMA Pediatrics (2022)
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Frequency of adverse events in the placebo arms of COVID-19 vaccine trials: A systematic review and meta-analysis JAMA Open Network (2022)
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Placebos in chronic pain: evidence, theory, and use in clinical practice. BMJ (2020).
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Conditioned open-label placebo for opioid reduction after spine surgery: a randomized controlled trial PAIN (2021)
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Open-label placebo vs double-blind placebo for irritable bowel syndrome: a randomized clinical trial PAIN (2021)
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Open-label placebo for chronic low back pain: a 5-year follow-up PAIN (2020)
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Open-label placebos for menopausal hot flushes: a randomized controlled trial Scientific Reports (2020)
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Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice BMJ (2020)
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Open label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits? BMJ (2018)
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Symptom perception, placebo effects, and the Bayesian brain. PAIN (2018).
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Open-label placebo treatment for cancer-related fatigue: A randomized-controlled clinical trial Scientific Reports (2018)
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Learned Immunosuppressive placebo responses in renal transplant patients PNAS (2018) 5.
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Certainty of genuine treatment increases drug responses in intellectually disabled patients Neurology (2017)6
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Open-label placebo treatment in chronic low back pain: a randomized controlled trial PAIN (2016)
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Placebo Effects in Medicine. New England Journal of Medicine (2015)
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Altered placebo and drug labeling changes the outcome of episodic migraine attacks Science Translational Medicine (2014)
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Active albuterol or placebo, sham acupuncture, or no intervention in asthma. New England Journal of Medicine (2011)
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Placebos without deception: A randomized controlled trial in irritable bowel syndrome. PLoS One (2010)
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Components placebo effect: Randomised controlled trial in patients with irritable bowel syndrome. BMJ (2008)
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Sham device v inert pill: Randomised controlled trial of two placebo treatments. BMJ (2006)
Basic Science Research
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Placebo effects and neuromodulation for depression: A meta-analysis and evaluation of shared mechanisms. Molecular Psych (2022)
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Reward and empathy in the treating clinician: the neural correlates of successful doctor-patient interactions Translational Psychiatry (2020)
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Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction Science Advances (2020)
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Network analysis of the genomic basis of the placebo effect JCI INsight (2017)
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Genetics and the placebo effect: the placebome. Trends in Molecular Medicine (2015)
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Classical conditioning of analgesic and hyperalgesic pain responses without conscious awareness. PNAS (2015)
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A neural mechanism for nonconscious activation of conditioned placebo and nocebo responses. Cerebral Cortex (2014)
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Sharing pain and relief: neural correlates of physicians during treatment of patients. Molecular Psychology (2013)
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Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel sy-ndrome. PLoS ONE (2012)
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Nonconscious activation of placebo and nocebo pain responses. PNAS (2012)
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A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect. Journal of Neuroscience (2008)
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Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. Journal of Neuroscience (2006)
Social Science Research
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The effect of singular nonverbal behaviors of experimenters on pain reports. J Pain Research (2024)
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Placebos in pediatrics: A cross-sectional survey investigating physicians' perspectives. J Psychosom Res (2023)
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Doctors Speak: A qualitative study of physicians' prescribing of antidepressants in functional bowel disorder. Cult Med Psychiatry (2022)
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Psychological predictors of response to open-label versus double-blind placebo: a randomized controlled trial of irritable bowel syndrome. Psychosomatic Medicine (2022)
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"Let's see what happens": Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial. PLoS One (2022)
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Patients' experiences treated with open-label placebo versus double-blind placebo: a mixed methods qualitative study. BMC Psychology (2022)
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Doctors Speak: A qualitative study of physicians' prescribing of antidepressants in functional bowel disorders Cult Med Psychiatry (2022)
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Surgeons' behaviors and beliefs regarding placebo effects in surgery Acta Orthopaedica (2021)
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Placebo studies and ritual theory: A comparative analysis of Navajo, acupuncture and biomedical healing. Phil. Trans. R. Soc. B (2011)
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Scientific tools, fake treatments, or triggers for psychological healing: How clinical trial participants conceptualise placebos Social Science and Medicine (2012)
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‘‘Maybe I made up the whole thing’’: Placebos and patients’ experiences in a randomized controlled trial. Culture, Medicine and Psychiatry (2009)
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Patient and practitioner influences on the placebo effect in irritable bowel syndrome. Psychosomatic Medicine (2009)
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Which patients improve: Characteristics increasing sensitivity to a supportive patient–practitioner relationship. Social Science and Medicine (2009)
Theoretical, Methodological, and Philosophical Analyses
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Open-label placebo: reflections on a research agenda. Perspectives in Biology and Medicine. (2018).
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The placebo effect: Illness and interpersonal healing. Perspectives in Biology and Healing (2009)
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The placebo effect in alternative medicine: Can the performance of a healing ritual have clinical significance? Annals of Internal Medicine (2002)
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Do medical devices have enhanced placebo effects? Journal of Clinical Epidemiology (2000)
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Powerful placebo: The dark side of the randomised controlled trial. Lancet (1998)
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Placebo effect studies are susceptible to response bias and other types biases. Journal of Clinical Epidemiology (2011)
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Effect of interpretive bias on research evidence. BMJ (2003).
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The double-blind, randomized, placebo-controlled trial: Gold standard or golden calf? Journal of Clinical Epidemiology (2001)
Bioethical Analyses
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Informed consent and clinical trials: where is the placebo effect? BMJ (2017)
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Are open-label placebos ethical? Informed consent and ethical equivocations Bioethics (2016)
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Deception of subjects in neuroscience: An ethical analysis. Journal of Neuroscience (2008)
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Sham procedures and the three ethics of clinical trials. Journal of the Royal Society of Medicine (2004)
Historical Analyses
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Heresy, witchcraft, Jean Gerson and the use of placebo controls. J Roy Soc Med (2023)
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Placebos in 19th century medicine: a quantitative analysis of the BMJ. BMJ (2012)
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Placebo controls, exorcisms, and the devil. Lancet (2009)
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Unbiased divination, unbiased evidence, and the patulin clinical trial. International Journal of Epidemiology (2004)
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Intentional ignorance: A history of blind assessment and placebo controls in medicine. Bulletin of the History of Medicine (1998)
East Asian Medicine and Acupuncture
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A Conversation with a Key Architect of Modern TCM in the West - Professor Ted Kaptchuk Chinese Medicine and Culture (2024)
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A systematic study of acupuncture practice: acupoint usage in an outpatient setting in Beijing, China Complementary Therapies in Medicine
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Placebo effects in acupuncture. Medical Acupuncture (2020)
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Rewiring the primary somatosensory cortex in carpal tunnel syndrome with acupuncture. BRAIN (2017)
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The case of acupuncture for chronic low back pain. SPINE (2011)
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Recent clinical trials of acupuncture in the West: responses from the practitioners. Chinese Journal of Integrative Medicine (2010)
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Acupuncture trials and informed consent. Journal of Medical Ethics (2007)
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Patient characteristics for outpatient acupuncture in Beijing, China. Journal of Complementary and Alternative Medicine (2004)
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Acupuncture: Theory, efficacy, and practice. Annals of Internal Medicine (2002)
Medical Pluralism
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The need to act a little more 'scientific': biomedical researchers investigating complementary and alternative medicine. Sociology of Health & Illness (2010).
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Varieties of healing. 1: Medical pluralism in the United States. Annals of Internal Medicine (2001)
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Varieties of healing. 2: A taxonomy of unconventional healing practices. Annals of Internal Medicine (2001)
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Medical malpractice implications of alternative medicine. Health Law and Ethics (1998).
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The persuasive appeal of alternative medicine. Annals of Internal Medicine (1998)
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Courses involving complementary and alternative medicine at US medical schools. JAMA (1998)
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Chriopractic: Origins, controversies, and contributions. Archives of Internal Medicine (1998)